Edward Hall was the son of Richard Edward Hall, and was a former apprentice of his father. He was one of the original three surgeons at MRI, where he remained until his resignation in 1790. He then helped Charles White and his brother Richard establish the Lying-in Hospital (St Mary's) and was appointed man-midwife extraordinary there.
Hall was a Jacobite and was alleged to have been responsible for removing the heads of the executed Manchester Jacobites, Thomas Deacon and Thomas Sydall from the spikes upon which they were fixed on the Exchange Building in Manchester. Hall was a member of the Manchester Literary and Philosophical Society.