Spence, the father of John and Joshua Spence, was a surgeon. He practised in Bedale then came to Manchester when his son John took over his Bedale practice in the late 1820s. In 1838, he was joined in his Manchester practice by his youngest son Joshua. When Joshua died the following year, John joined his father in Manchester. William retired to Dalton-in-Furness around 1850.
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