In 1746 John Lowe (1704-1771) of Denby, Derbyshire purchased the Locko estate, the site of a former leper house, at Spondon, Derbyshire, from the Gilbert family. The Lowe family traces its origins back to Thomas Lowe (d 1415) of Macclesfield, Cheshire and Alderwasley, Derbyshire, whose grandson Lawrence acquired by marriage, property in Denby, the main family home until the purchase of Locko.
On John's death in 1771, Locko passed to his brother Richard (1716-1785), a woollen draper in Covent Garden, London, whose many interests included banking businesses in London and Manchester and supplying the army with clothing.
Like his brother John, Richard died without children and the family estates passed to William Drury (1753-1827) of Nottingham. William Drury's grandmother, Anne Lowe, was the daughter of John Lowe (1642-1722) of Denby and the aunt of brothers John and Richard Lowe. She married William Drury of Nottingham and Oakham, Leicestershire.
Following his inheritance, William Drury assumed the name of Lowe by Royal Sign Manual dated 10 July 1790. He also had no son to succeed him. His only daughter, Mary Anne (1783-1840), eloped to Gretna Green in 1800 with Robert Holden (1769-1844) of Darley Abbey, Derbyshire.
Robert Holden and Mary Anne did not actually occupy Locko as William Drury Lowe's widow outlived them both. Upon her death in 1849, in her 104th year, the Lowe estates passed to their eldest son, William Drury Holden, who assumed the name and arms of Lowe in 1853. In 1819 Robert Holden had purchased the Nuthall Temple estate in Nottinghamshire and this and other Holden lands passed to William's younger brother Robert (1805-1872).
William Drury Lowe (Holden) was a great collector of paintings with a fascination for Italian art and culture. When he died in 1877 he was succeeded by his son William Drury Nathaniel Lowe (1828-1906) who obtained licence in 1884 to take the additional name of Drury and to bear the arms of Drury quarterly with Lowe. Two of William's younger brothers, Sir Drury Curzon Drury-Lowe (1830-1908) and Robert Henry Curzon Drury-Lowe (1831-1907) had particularly distinguished military careers.
William Drury Nathaniel Drury-Lowe was succeeded by his son William Drury Drury-Lowe (1877-1916) who was killed during the First World War. Locko passed to his brother John Alfred Edwin Drury-Lowe (1881-1949). John married Dorothy Casberd-Boteler in 1905 and was succeeded by their son John D B Packe-Drury-Lowe (1905-1960).