Misc Leukaemia Figures, Drugs Etc.

Scope and Content

The file contains a significant amount of data on the haematological effects on specific patients following treatment with certain drugs, mostly those used in chemotherapy. Firstly there are a number of full daily blood counts for 6 named patients suffering from acute leukaemia being treated with aminopterin in 1948/9. The rest of the data describes patients by their initials only and deals with patients suffering from chronic lymphatic leukaemia, chronic myeloid leukaemia, Hodgkin's disease, acute myeloblastic leukaemia, acute lymphatic leukaemia, mycosis fungoides, reticulosis, immature cell erythraemia, stem-cell leukaemia, myelomatosis, and lymphosarcoma. These tables record such information as the patient number, patient initials, sex, age, date treatment was started, date of death, months of survival, their diagnosis, the drug used, and in some instances the number of grams administered.

The drugs these patients were being treated with include demecolcine; thiotepa; p-(Di-2-chloroethylamine)-phenylbutyric Acid (CB 1348); TEM; nitrogen mustard T.773; urethane; ACTH; cortisone; 6-mercaptopurine; mercloran; di(2-chloroethyl)-beta-naphthylamine (R48). There are some tables towards the end of the file with more detailed information regarding the effects of R48.

The file also contains a number of rough handwritten notes that appear to relate to the treatment of patients with Hodgkin's disease, mainly using R48 and T.773. In addition there are two copies of an information leaflet published by Burroughs Wellcome & Co. relating to Leukeran, a branded form of chlorambucil.

Conditions Governing Access

This file contains personal medical information of several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.