Nitrogen Mustards

Scope and Content

Three reports on the exposure to war gases all marked secret:

  • 'The Pharmacodynamics of the Nitrogen Mustards' by Alfred Gilman, Louis Goodman, and Frederick S. Philips with the assistance of Roberta Allen. The paper is headed H.Q.C.D.E.S. Porton, 8 April 1943 and is divided into three sections, namely: (A) The relationship between chemical constitution and pharmacodynamic action of the nitrogen mustards and their transformation products; (B) The use of thiosulfate as an antidote against the systemic effects of TL 146, thiosulfate clearance in humans; (C) The human response to the intravenous injection of TL 145-HC1. (with Thomas Dougherty and Jean Dougherty).
  • University of Chicago Toxicity Laboratory Report No. 27. 'A Study of the Haematological Changes Following Exposure to Certain War Gases' by C. C. Lushbaugh, dated 24 February 1943.
  • Informal monthly progress report on contract B4-C. B292. OEMsr-556. Dated 21 December 1942. Official Investigator, Homer W. Smith. Looks at TL 146 in sections entitled imine bone and leucotoxic action, adrenalextomized rats, oral administration, and intrasplenic administration.

The rest of the file contains data on 7 named cases detailing a series of full blood counts alongside the regular administration of T773 from 1944. It is not immediately clear what specific piece of research they relate to other than the investigation of the treatment of leukaemias with nitrogen mustards.

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