Leukaemia - Azauridine

Scope and Content

Reports and data relating to a trial of 6-Azauridine in patients with leukaemia by Wilkinson in 1961-1962 as well as reports from other trials. This includes correspondence from C.N. Brown of The Distillers Company (Biochemicals) Limited regarding supplies of azauridine and sending a copy of a paper given at the New York Academy of Sciences in November 1961 by Dr Arnold Welch entitled '6-Azauridine: An Antileukaemic Agent with Unusual Biochemical Properties'; copy of minutes from Consultants' Meeting heled at the Piccadilly Hotel, London on 14 May 1962 and chaired by C.N. Brown in which Wilkinson gives a brief account of his preliminary trials; two individual patient reports of individuals involved in Wilkinson's trial; 8 photographs of cells and chromosomes; a small number of Wilkinson's handwritten notes; and a typescript copy of an article published as Elves, M.W., Buttoo, A.S., Israëls, M.C.G., & Wilkinson J.F., 'Chromosome Changes Caused by 6-Azauridine During Treatment of Acute Myeloblastic Leukaemia', British Medical Journal, 1963, Vo. 1(5324), pp.156-159.

In addition to material relating to Wilkinson's work with 6-Azauridine there are reports from other trials. This includes a report of a visit to Prague to discuss clinical trials of azauridine with representatives of spofa & clinicians in Czechoslovak hospitals by Drs C.N. Brown & D.M. Burley in June & July 1961 with some accompanying case reports. There are also abstracts of Fallon, H.J. & Frei, E. III, 'Clinical & Biochemical Effects of 6 Azauridine in Leukaemia', Proceedings of the American Association of Cancer Research, 1961, 3(224) and Handschumacher, R.E. & Cardoso, S.S., 'Alterations in Human Pyrimidine Metabolism caused by 6-Azauridine', Proceedings of the American Association of Cancer Research, 1961, 3(232).

Seemingly unrelated to the azauridine trials the file also contains a number of photos of equipment and charts relating to the preparation of hog's stomach and a large series of numbered paragraphs or abstracts seemingly relating to a range of different investigations and papers about a variety of instances of leukaemia and its treatment including instances seen in survivors from Hiroshima and Nagasaki.

Access Information

This file contains personal medical information of several individuals that is less than 100 years old and closed under the terms of the Data Protection Act 1998. Please consult the archivist before issuing.