G.V.Wigram was born 28th March 1805 in Walthamstow, Essex. He was the twentieth son of Sir Robert Wigram, a wealthy merchant and shipowner, and Eleanor Wigram (née Watts). Wigram was a close friend and associate of J.N. Darby and a key figure in the Plymouth Brethren movement. Two of his brothers also achieved fame: James Wigram became Vice Chancellor of the Old Court of Chancery, whilst Joseph Cotton Wigram became Bishop of Rochester.
Wigram enrolled in the army as a subaltern officer where he experienced a conversion in 1824 and then made contact with the Bourg-de-Four Assembly in Geneva, where he met Thomas Erskine. He left the army and enrolled at Queen's College, Oxford where he met Benjamin Willis Newton, James L. Harris, William Jarratt and others who were to become prominent figures in the Plymouth Brethren movement. Initially drawn to a career as a Church of England minister, his ambition was frustrated by Bishop Blomfield who refused to ordain him because of his extreme evangelical views. He met J.N. Darby in 1827 at Oxford and joined the Plymouth Brethren.
He spent time at Powerscourt in Cork (September 1830-March 1831) before leaving for Devon (invited by Newton) and purchasing a chapel in Raleigh Street, Plymouth, which came to be known as Providence Chapel. He used his wealth to publish religious writings, notably his concordances: The Englishman's Greek and English Concordance to the New Testament in 1839, and The Englishman's Hebrew and Chaldee Concordance of the Old Testament in 1867. These were very influential among Bible students with limited knowledge of Greek or Hebrew. He also compiled two prayer volumes; Hymns for the Poor of the Flock, 1837-38 and Hymns for the Little Flock in 1856. In 1831 he published A Protest against the National Establishment of England and in 1867 he edited The Herbraist's Vade Mecum with W. Chalk. Notes from his teachings were edited by Edward Dennett and published as Memorials of the Ministry of G.V. Wigram and Gleanings from the Teachings of G.V. Wigram. He later moved to London to continue his teachings.
He had several clashes with other figures in the movement, including Percy Frances Hall on the issue of the doctrine of the secret rapture. He stood by Darby in the 1860s on the question of the doctrine of the suffering of Christ which had produced dissension within the movement.
He married twice but both wives died before him, as did his daughter Fanny. His first wife (who he married in 1834) was Fanny Bligh, the daughter of Thomas Chebury Bligh. His second wife was Catherine Parnell (who he married in 1835). She was the daughter of William Parnell and aunt of the Irish politician Charles Stewart Parnell. He was grief stricken after the death of his daughter and spent the rest of his life making visits to the West Indies and New Zealand.
Wigram died at his house, 45 Cumberland Place, London on 1st January 1879.