This is an unbound essay consisting of 18 folios with the original pagination pp.1-36. P.1 is headed with the note 'Dr Edmund Lyon's MS' in the hand of Samuel Crompton and also the stamp of the Victoria University of Manchester. It is signed by Lyon on the final page and dated September 1814.
Lyon outlines his intention in the introduction to enquire into the nature of a compound fracture and the circumstances by which it is so materially different from a simple fracture of the bones of the extremities. He discusses the nature of the injury and then divides it into three classes of cases where either the limb can be saved, needs immediate amputations, or requires amputation later owing to infection or failure to heal.