The volume has the original pagination pp.1-337, the writing is largely on the recto of each page with occasional notes on the verso and there is a subject index in the rear. This is volume 1 of 5 and begins with lecture 1 and finishes part way through lecture 26; the start of each new lecture is clearly marked, although they are not dated. There is a note on the first page on 'Antiquity of Medicine' before the lecture notes begin.
The contents of the lectures according to the index are as follows: introduction; history of physic; general view of the human machine; best plan for studying physic; necessary qualifications for studying physic; division of the course; simple solid & cellular texture; Dr B. Robinson's experiments of different states of the simple solids; sources of tension of the simple solid; compound solid; diseases of the simple solid; scale of remote causes acting on the simple solid; general laws of the nervous system; the nervous system.
The volume bears the bookplate of the Radford Library, Saint Mary's Hospital, Manchester, which also indicates that it was allocated the reference number Q126 viz. their 1877 catalogue. The volume has since been referenced J6 C66 as part of an alternative system. The spine reads 'Cullen's Institutions Vol.1'.