In explaining the index he has employed at the beginning of the manuscript Hull describes this volume as a commonplace book. His index is very simple and lists the 26 letters of the alphabet with 5 rows next to each, one for each letter of the alphabet. Alongside these are a series of page numbers but there are no further detailed descriptions of what is on the page. He explains that each subject is indexed by its first letter and the first subsequent vowel, e.g. page numbers containing topics relating to 'beauty', 'bread', and 'blemishes' would all be listed together alongside 'Be' in the index. The majority of the text is in longhand but there are sections in shorthand using the Byrom system.
The manuscript contains notes on a wide array of medical subjects including: Dover's powder, immoderate flux of the menses, injections in the gonorrhoea, opium, circulation in the foetus, a table of heating mixtures from Dr Cullen's chemistry, hernia, venereal disease, exanthemata, exhalants, dysentery, digestion, antiseptics, fixed air, duration of paroxysms in intermittents, remarks on contagion and miasmata, death, formation of fur upon the tongue, tobacco, debility, food, club foot, bleeding, excitement, dilation of the pupil, diseases of the eye, fermentation, hysteria, blistering, bile, jaundice, smelling, the sinuses, why right hand used in preference to the left, dropsy, worms, kidney, the penis, how nutrition is performed, muscles, why bones are hollow, blood, the stone, incontinence of urine, ascites, haemorrhoids, hydrocephalus, hydrothorax, observations on the recovery of drowned persons, ganglion, sympathetic action of the stomach, scirrhous and cancer, wry neck [torticollis], smallpox, luxations [dislocations], fractures, laceration of tendons, generation, cartilage, female organs of generation, various materia medica arrangements (of Dioscorides, Étienne François Geoffroy, John Frederick Cartheuser, John Murray, Francis Home, Andrew Duncan), hydrophobia [rabies], and circulation of blood in the encephalon [brain].
Towards the end of the volume there are a few separate entries recording some specific cases, presumably seen by Hull. These are all in shorthand with occasional longhand words and are as follows:
- Ascites, Alice Pilkington of Nova Scotia, Blackburn, age 35
- Compound dislocation, James Holker, age 18
- Hernia cruralis, Ellen Livesey-Darwen, near Blackburn, age 45
- Margaret Waddington, age 21, has 5 children
- An extraordinary retention of faeces, William Lever's child
- A wound penetrating to knee joint, Daniel Kay (no further details of case)
- Colica calculosa, George Duckworth