Leo Grindon taught botany at the Royal Manchester School of Medicine. After leaving school at thirteen, Grindon came to Manchester from Bristol in 1838 to become a cashier. During this time, he taught himself botany and became an eminent botanist, publishing a number of works on the subject. He was a lecturer in botany at the medical school from the 1850s, although he continued working in business until 1864, fitting in lectures around his job. He was not kept on as a lecturer when the medical school was amalgamated with Owens College Manchester in 1872. Grindon's botanical collection is housed at the Manchester Museum.